In a large mixing bowl, combine the flour, paprika, garlic powder, onion powder, cayenne pepper, salt, and black pepper. Mix well.
Pour the buttermilk into a shallow dish. Dip each chicken thigh into the buttermilk, then dredge it in the seasoned flour mixture until fully coated. Set aside.
In a deep frying pan, heat oil over medium-high heat until it reaches 350°F (175°C). Carefully place the coated chicken thighs in the hot oil and fry for 6-8 minutes per side or until golden brown and cooked through. Remove and drain on paper towels.
Preheat your oven to 425°F (220°C). In a mixing bowl, whisk together the flour, baking powder, and salt. Add the cold cubed butter and mix until crumbly. Stir in the buttermilk until a soft dough forms.
Turn the dough onto a floured surface and gently knead it a few times. Pat it into a 1-inch thickness and cut using a biscuit cutter or a glass. Place the biscuits on a baking sheet lined with parchment paper.
Bake the biscuits in the preheated oven for 12-15 minutes or until golden brown.
In a small saucepan over low heat, combine the honey, red pepper flakes, and apple cider vinegar. Stir until mixed and heated through. Remove from heat.
Assemble the Hot Honey Chicken Biscuits by placing a fried chicken thigh between two biscuits and drizzling with hot honey sauce.