Preheat your smoker or grill to 225°F (107°C).
Prepare the jalapeños by slicing them in half lengthwise and removing the seeds and membranes (use gloves if desired to avoid spicy oils).
In a mixing bowl, combine the smoked brisket, cream cheese, shredded cheddar cheese, garlic powder, onion powder, smoked paprika, and a pinch of salt and pepper. Mix well until all ingredients are combined.
Stuff each jalapeño half generously with the brisket mixture.
Wrap each stuffed jalapeño with a slice of bacon, securing it with a toothpick if necessary.
Place the wrapped jalapeños on a baking tray lined with aluminum foil.
Once the smoker or grill is preheated, place the baking tray with the jalapeños in it. Smoke for about 60 minutes, or until the bacon is crispy and the cheese is melted.
Remove from the smoker or grill and let them cool for a few minutes before serving.
Optional: Drizzle with BBQ sauce for extra flavor before serving.